MarThe CRISPR Cas gene editing system has been used to identify more than synthetic lethal gene interactions in cancer cells.
FastSL A MATLAB toolbox to rapidly evaluate synthetic lethal sets in organisms using the genome scale metabolic models.
Synthetic Lethal Interactions of MDS Associated Spliceosomal Gene Mutations Identifies the Basis for Their Mutual ExclusivityStanley Chun Wei LeeKhrystyna
Synthetic lethality screeningIsogenic pairs of X MAN Cell Lines allow gene mutations to be studied without the potentially confounding influence of
Synthetic lethality arises when a combination of deficiencies in the expression of two or more genes leads to cell deathwhereas a deficiency in only one of
Finding synthetic lethalities combines techniques used for finding biomarkers and screening for drug candidatesDespite all we know about DNA repair
JunA synthetic lethal interaction occurs between two genes when the perturbation of either gene alone is viable but the perturbation of both genes
NovSynthetic lethality occurs when the simultaneous perturbation of two genes results in cellular or organismal deathSynthetic lethality also
Two genes are synthetic lethal if mutation of either alone is compatible with viability but mutation of both leads to deathSotargeting a gene that is synthetic
JulSecond synthetic lethal interactions may be mapped by directed combinatorial disruptions in human cell linesSuch disruptions use pairwise
Julin metabolic networks is known as plasticity synthetic lethality (PSL)of paired functional and silent metabolic reactions or genes is lethal
Synthetic lethal targeting of cancer cells could be therapeutically advantageous to targeting of cancer cells with standard agentsin that only the cancer cells with
SepSynthetic lethality is traditionally defined as a condition where simultaneous mutation in two genes but not either alone leads to cell death
The synthetic lethal screen is a method of isolating novel mutants whose survival is dependent on a gene of interestCombining the colony color assay with a
In order to decipher the genetic determinants of this antibiotic resistanceLun et alused a screen called gene compound synthetic lethality (GCSL) which
This synthetic lethal toxicity relationship between FLT and KIT for maintaining normal hematopoietic populations may explain the adverse side effects of the
MayThe synthetic lethal siRNA screen was done as previously described Briefly we utilized a custom siRNA library targeting known DNA
Address:N0.2500,Xiupu Road, Kangqiao Industrial Area, Pudong, Shanghai
TEL: (+86) 21 51095826
Email: [email protected]Thank you for browsing our site to learn more about us! Please share your comments, feedback, and suggestions regarding your experience with WPC partners. We will continue to improve our products and services.Copyright ? WPC Co Ltd. All rights reserved.